Cytokines and pregnancy: Potential regulation by histone deacetylases,Molecular Reproduction and Development

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Cytokines and pregnancy: Potential regulation by histone deacetylases
Molecular Reproduction and Development ( IF 2.7 ) Pub Date : 2021-04-26 , DOI: 10.1002/mrd.23430
Sheryl K Munro ₁ , Biju Balakrishnan ₁ , Abbey C Lissaman ₁ , Palak Gujral ₁ , Anna P Ponnampalam _{1,

2,

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Affiliation

Cytokines are important regulators of pregnancy and parturition. Aberrant expression of proinflammatory cytokines during pregnancy contributes towards preterm labor, pre-eclampsia, and gestational diabetes mellitus. The regulation of cytokine expression in human cells is highly complex, involving interactions between environment, transcription factors, and feedback mechanisms. Recent developments in epigenetic research have made tremendous advancements in exploring histone modifications as a key epigenetic regulator of cytokine expression and the effect of their signaling molecules on various organ systems in the human body. Histone acetylation and subsequent deacetylation by histone deacetylases (HDACs) are major epigenetic regulators of protein expression in the human body. The expression of various proinflammatory cytokines, their role in normal and abnormal pregnancy, and their epigenetic regulation via HDACs will be discussed in this review.

中文翻译：

细胞因子和妊娠：组蛋白去乙酰化酶的潜在调节

细胞因子是怀孕和分娩的重要调节剂。怀孕期间促炎细胞因子的异常表达导致早产、先兆子痫和妊娠糖尿病。人体细胞中细胞因子表达的调控非常复杂，涉及环境、转录因子和反馈机制之间的相互作用。表观遗传研究的最新进展在探索组蛋白修饰作为细胞因子表达的关键表观遗传调节剂及其信号分子对人体各种器官系统的影响方面取得了巨大进步。组蛋白乙酰化和随后的组蛋白去乙酰化酶 (HDAC) 的去乙酰化是人体内蛋白质表达的主要表观遗传调节剂。各种促炎细胞因子的表达，

更新日期：2021-06-11

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