Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor,Nanoscale Horizons

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Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor
Nanoscale Horizons ( IF 8.0 ) Pub Date : 2021-4-21 , DOI: 10.1039/d0nh00685h
Jincheng Tong ₁ , Amadou Doumbia ₁ , Michael L Turner ₁ , Cinzia Casiraghi ₁

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Monitoring crystallization events in real-time is challenging but crucial for understanding the molecular dynamics associated with nucleation and crystal growth, some of nature's most ubiquitous phenomena. Recent observations have suggested that the traditional nucleation model, which describes the nucleus having already the final crystal structure, may not be valid. It appears that the molecular assembly can range during nucleation from crystalline to partially ordered to totally amorphous phases, and can change its structure during the crystallization process. Therefore, it is of critical importance to develop methods that are able to provide real-time monitoring of the molecular interactions with high temporal resolution. Here, we demonstrate that a simple and scalable approach based on interdigitated electrode array sensors (IESs) is able to provide insights on the dynamics of the crystallization process with a temporal resolution of 15 ms.

中文翻译：

使用叉指阵列电极传感器实时监测溶液中的结晶

实时监测结晶事件具有挑战性，但对于理解与成核和晶体生长（自然界中最普遍的一些现象）相关的分子动力学至关重要。最近的观察表明，描述已经具有最终晶体结构的核的传统成核模型可能无效。看来分子组装在成核过程中可以从结晶相到部分有序相到完全无定形相，并且可以在结晶过程中改变其结构。因此，开发能够以高时间分辨率实时监测分子相互作用的方法至关重要。在这里，我们证明了一种基于叉指电极阵列传感器 (IES) 的简单且可扩展的方法能够以 15 毫秒的时间分辨率提供有关结晶过程动力学的见解。

更新日期：2021-04-27

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