The city of Puno in Peru is the largest producer of trout (Oncorhynchus mykiss) using intensive floating cage systems installed in Lake Titicaca. As a result, the increase in diseases and the use of antibiotics to control them during the production cycle has been documented. We study the impact of antibiotics on drinking water, trout tissues and the lake's aquatic ecosystem. Nine antibiotics were monitored: tetracyclines, sulfonamides and fluoroquinolones. The samples were collected randomly and analyzed by liquid chromatography coupled to mass spectrometry and the solid-phase extraction system. The sediment samples and surface water samples contain high concentrations of antibiotics. All sediments contain fluoroquinolones (3.74 mg kg⁻¹) and tetracyclines (3.08 mg kg⁻¹) and the surface water contains fluoroquinolones of up to 408.2 and 652.7 ng L⁻¹ in the dry and rainy seasons respectively (P > 0.05). Drinking water samples from the city of Puno collected at sampling points with Lake Titicaca as a source of drinking water, reached an average of 188.1 and 222.2 ng L⁻¹ of ciprofloxacin in dry and rainy seasons respectively. Complementarily, in trout tissues, it reached 7.8 μg kg⁻¹ in oxytetracycline 8.7 μg kg⁻¹ in sulfatizole, 4.2 μg kg⁻¹ in ciprofloxacin and 3.6 μg kg⁻¹ in sarafloxacin. The presence of these antibiotics in surface water is attributed to the aquaculture activity, in addition to runoff and wastewater, and their presence can have detrimental effects on the aquatic ecosystem, and even affect public health due to the consumption of aquaculture products and drinking water contaminated with antibiotic residues.

秘鲁的普诺市是最大的鳟鱼 ( Oncorhynchus mykiss )生产商，使用安装在的的喀喀湖的密集浮动网箱系统。因此，疾病的增加以及在生产周期中使用抗生素来控制疾病已经被记录在案。我们研究抗生素对饮用水、鳟鱼组织和湖泊水生生态系统的影响。监测了九种抗生素：四环素、磺胺类和氟喹诺酮类。随机采集样品，采用液相色谱-质谱联用和固相萃取系统进行分析。沉积物样品和地表水样品含有高浓度的抗生素。所有沉积物均含有氟喹诺酮类（3.74 mg kg ^-1）和四环素（3.08 mg kg ^-1)，地表水在旱季和雨季分别含有高达408.2 和652.7 ng L ^{-1 的}氟喹诺酮类药物(P > 0.05)。在以的的喀喀湖为饮用水源的采样点采集的普诺市饮用水样品，在旱季和雨季分别达到平均 188.1 和 222.2 ng L ^-1的环丙沙星。互补地，在鳟鱼组织，则达到7.8微克千克^-1在土霉素8.7微克千克^-1在sulfatizole，4.2微克千克^-1环丙沙星和3.6微克千克^-1在沙拉沙星中。除了径流和废水外，地表水中这些抗生素的存在归因于水产养殖活动，它们的存在会对水生生态系统产生不利影响，甚至因食用水产养殖产品和饮用水受到污染而影响公众健康与抗生素残留。