Copper ions play various roles in mammalian cells. Some investigations indicated that copper correlates with liver fibrosis and changes in bone marrow cells. Here, we explored the role of bone marrow cell parameters in copper liver fibrosis development and possible underlying mechanisms. The age-related features of biochemical indicators, bone marrow cell parameters, and electrical conductivity of 3- and 20-month-old male Wistar rats treated with copper II sulfate pentahydrate (CuSO₄ × 5H₂O) have been investigated. Based on the obtained earlier experimentally data in our laboratory, dose of 1 mg/100 g (0.58 mg/g of liver) was used. Induced liver fibrosis caused a change in the number and ratio of morphotypes of bone marrow cells, calcium and copper content, redox-system activity. These parameters depended of animals‘ age and presence of liver fibrosis. We also demonstrated that electrical conductivity can be used as integral parameter. In conclusion, the “adaptive response” modifies the emerging reactions of the organism to new external factors.

铜离子在哺乳动物细胞中扮演着不同的角色。一些研究表明，铜与肝纤维化和骨髓细胞的变化有关。在这里，我们探讨了骨髓细胞参数在铜肝纤维化发展中的作用以及可能的潜在机制。五水二硫酸铜（CuSO ₄  × 5H ₂O) 已被调查。根据我们实验室早期获得的实验数据，使用的剂量为 1 mg/100 g（0.58 mg/g 肝脏）。诱导肝纤维化引起骨髓细胞形态类型、钙和铜含量、氧化还原系统活性的数量和比例的变化。这些参数取决于动物的年龄和肝纤维化的存在。我们还证明了电导率可以用作积分参数。总之，“适应性反应”改变了有机体对新的外部因素的新反应。