A low response rate is the major challenge for existing cancer immunotherapies. Physical cues in the tumor microenvironment (TME) have been recognized as new hallmarks of cancer, which may synergistically contribute to low immunotherapy response. Recent evidence indicates that the physical hallmarks of cancer hold great potential as new targets for improved immunotherapy.

中文翻译：

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癌症物理标志作为改进免疫疗法的新靶点

低反应率是现有癌症免疫疗法的主要挑战。肿瘤微环境 (TME) 中的物理线索已被认为是癌症的新标志，这可能协同导致低免疫治疗反应。最近的证据表明，癌症的物理特征具有作为改进免疫疗法的新靶点的巨大潜力。