Hypertension is a highly prevalent condition, affecting nearly 50% of the US adult population,^1,2 and it is a major, modifiable risk factor for coronary heart disease, stroke, kidney disease, and heart failure.^1,3 Most people with hypertension have no signs or symptoms; therefore, hypertension is usually detected through screening. However, blood pressure (BP) levels vary physiologically throughout the day and night, so characterizing an individual’s true or accurate BP level is challenging.⁴ It is possible to measure BP levels in different settings, including in the clinician’s office, using self-monitoring at home, or via ambulatory monitoring over 24 hours, expanding the possible means for detecting and defining hypertension. To date, BP levels measured in the office setting have been the primary approach to diagnose hypertension and guide the initiation and titration of antihypertensive medication. However, for many individuals, BP levels differ substantially when measured inside vs outside the office.

高血压是一种高度流行的病症，影响了近 50% 的美国成年人口，^1,2并且它是冠心病、中风、肾病和心力衰竭的主要、可改变的危险因素。^{1 ,3}大多数高血压患者没有任何体征或症状；因此，高血压通常是通过筛查发现的。然而，血压 (BP) 水平在白天和晚上都会发生生理变化，因此表征个人真实或准确的 BP 水平具有挑战性。⁴可以在不同的环境中测量血压水平，包括在临床医生办公室、在家中使用自我监测或通过 24 小时的动态监测，从而扩展了检测和定义高血压的可能手段。迄今为止，在办公室测量的血压水平一直是诊断高血压和指导抗高血压药物开始和滴定的主要方法。然而，对于许多人来说，在办公室内和办公室外测量时，血压水平存在很大差异。