Context:

Pressure ulcers or injuries, arise from ischemic damage to soft tissues induced by unrelieved pressure over a bony prominence. They are usually difficult to treat with standard medical therapy and often they recur. In the search for better treatment options, promising alternative forms of treatment are today emerging. Within the field of regenerative medicine, ongoing research on advanced therapies seeks to develop medicinal products based on gene therapy, somatic cell therapy, tissue-engineering and combinations of these.

Objective:

The main objective is to perform an overview of experimental and clinical developments in somatic cell therapy and tissue engineering targeting the treatment of pressure injuries.

Methods:

Searching terms as “PRESSURE ULCER”, “STEM CELL THERAPY”, “TISSUE ENGINEERING” or “WOUND HEALING” were used in combination or alone, including publications refered to basic and clinical research and focusing on articles showing results obtained in a clinical context. A total of 80 references are cited, including 23 references published in the 3 last years.

Results:

The results suggest that this form of treatment could be an interesting option in patients with difficult-to-treat ulcers as spinal cord injury patients.

Conclusion:

This field of regenerative medicine is very broad and further research is warranted.

中文翻译：

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压疮治疗中的干细胞和组织工程方法

语境：

压力性溃疡或损伤是由骨突上未释放的压力引起的软组织缺血性损伤引起的。它们通常难以通过标准药物治疗进行治疗，并且经常复发。在寻找更好的治疗选择的过程中，如今出现了有前途的替代治疗形式。在再生医学领域，正在进行的先进疗法研究旨在开发基于基因疗法、体细胞疗法、组织工程及其组合的医药产品。

客观的：

主要目标是对针对压力性损伤治疗的体细胞疗法和组织工程的实验和临床发展进行概述。

方法：

搜索术语如“压疮”、“干细胞治疗”、“组织工程”或“伤口愈合”被组合或单独使用，包括涉及基础和临床研究的出版物，并侧重于显示在临床环境中获得的结果的文章。共引用参考文献80篇，其中近3年发表的参考文献23篇。

结果：

结果表明，对于像脊髓损伤患者这样难以治疗的溃疡患者，这种治疗形式可能是一种有趣的选择。

结论：

再生医学的这一领域非常广泛，需要进一步研究。