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Origins, Biology, and Diseases of Tissue Macrophages
Annual Review of Immunology ( IF 26.9 ) Pub Date : 2021-04-26 , DOI: 10.1146/annurev-immunol-093019-111748
Nehemiah Cox 1 , Maria Pokrovskii 1 , Rocio Vicario 1 , Frederic Geissmann 1
Affiliation  

Tissue-resident macrophages are present in most tissues with developmental, self-renewal, or functional attributes that do not easily fit into a textbook picture of a plastic and multifunctional macrophage originating from hematopoietic stem cells; nor does it fit a pro- versus anti-inflammatory paradigm. This review presents and discusses current knowledge on the developmental biology of macrophages from an evolutionary perspective focused on the function of macrophages, which may aid in study of developmental, inflammatory, tumoral, and degenerative diseases. We also propose a framework to investigate the functions of macrophages in vivo and discuss how inherited germline and somatic mutations may contribute to the roles of macrophages in diseases.

中文翻译:



组织巨噬细胞的起源、生物学和疾病



组织驻留型巨噬细胞存在于大多数组织中,具有发育、自我更新或功能属性,这些属性不容易符合教科书上关于源自造血干细胞的塑料和多功能巨噬细胞的描述;它也不符合促炎与抗炎的范式。这篇综述从进化的角度介绍并讨论了巨噬细胞发育生物学的最新知识,重点关注巨噬细胞的功能,这可能有助于发育、炎症、肿瘤和退行性疾病的研究。我们还提出了一个框架来研究巨噬细胞在体内的功能,并讨论遗传性种系和体细胞突变如何影响巨噬细胞在疾病中的作用。

更新日期:2021-04-27
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