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Dendritic Cells Revisited
Annual Review of Immunology ( IF 26.9 ) Pub Date : 2021-04-26 , DOI: 10.1146/annurev-immunol-061020-053707
Mar Cabeza-Cabrerizo 1 , Ana Cardoso 1 , Carlos M Minutti 1 , Mariana Pereira da Costa 1 , Caetano Reis e Sousa 1
Affiliation  

Dendritic cells (DCs) possess the ability to integrate information about their environment and communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a variety of cell types have been called DCs on the basis of phenotypic and functional attributes. Here, we refocus attention on conventional DCs (cDCs), a discrete cell lineage by ontogenetic and gene expression criteria that best corresponds to the cells originally described in the 1970s. We summarize current knowledge of mouse and human cDC subsets and describe their hematopoietic development and their phenotypic and functional attributes. We hope that our effort to review the basic features of cDC biology and distinguish cDCs from related cell types brings to the fore the remarkable properties of this cell type while shedding some light on the seemingly inordinate complexity of the DC field.

中文翻译:


重新审视树突状细胞

树突状细胞 (DC) 具有整合有关其环境的信息并将其传达给其他白细胞的能力,从而形成适应性和先天免疫。多年来,根据表型和功能属性,多种细胞类型被称为 DC。在这里,我们将注意力重新集中在常规 DCs (cDCs) 上,这是一种通过个体发生和基因表达标准分离的细胞谱系,最符合 1970 年代最初描述的细胞。我们总结了当前对小鼠和人类 cDC 亚群的了解,并描述了它们的造血发育及其表型和功能属性。

更新日期:2021-04-27
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