A 10-y-old intact male Labrador Retriever dog had a history of ataxia, inability to stand, and grand mal seizures. Complete blood count and serum biochemistry profiles revealed profound hypoglycemia, mildly increased alanine aminotransferase (ALT) activity, mild hypernatremia, and lymphopenia. The seizures could not be controlled with intravenous dextrose, diazepam, or propofol. The dog was euthanized given poor quality of life, and an autopsy was performed. Primary autopsy findings included firm hepatic masses that ranged from dark-red to tan, with the largest ~1.5 cm diameter, and pulmonary edema. Histologic examination of the hepatic masses revealed redundant, several-cell-thick cords, and packeted or acinar arrangements of polygonal cells, supported on a fibrovascular stroma. The neoplastic cells were immunopositive for insulin, synaptophysin, and neuron-specific enolase immunohistochemistry; granules in the tumor cells had an affinity for Grimelius silver stain. The histologic features, as well as the immunohistochemical staining profile, identified the neoplasm as a primary multifocal hepatic neuroendocrine carcinoma. Neuroendocrine carcinomas are rare in dogs and usually occur in the gastrointestinal or respiratory tract.

一只 10 岁的完整雄性拉布拉多犬有共济失调、无法站立和癫痫大发作的病史。全血细胞计数和血清生化特征显示严重低血糖、丙氨酸氨基转移酶 (ALT) 活性轻度升高、轻度高钠血症和淋巴细胞减少。静脉注射葡萄糖、地西泮或丙泊酚无法控制癫痫发作。由于生活质量差，这只狗被安乐死，并进行了尸检。初步尸检发现包括从暗红色到棕褐色的坚硬肝脏肿块，最大直径约 1.5 厘米，以及肺水肿。肝脏肿块的组织学检查显示有多余的、数个细胞厚的条索，以及由纤维血管基质支撑的多边形细胞的包装或腺泡排列。肿瘤细胞对胰岛素、突触素、和神经元特异性烯醇化酶免疫组化；肿瘤细胞中的颗粒对 Grimelius 银染色具有亲和力。组织学特征以及免疫组织化学染色特征将肿瘤确定为原发性多灶性肝神经内分泌癌。神经内分泌癌在狗中很少见，通常发生在胃肠道或呼吸道。