The hypertension (HTN) and type 2 diabetes mellitus (T2DM) are a common multifactorial disease due to genetics and environmental factors. The alpha 2B adrenergic receptor (α2B-AR) has relationship with secretion of insulin and mediates the vasoconstriction that elevate blood pressure. This study aimed to determine the association between α2B-AR gene polymorphism with HTN and T2DM in Saudi cases. 200 cases and 100 healthy controls from Saudi population were recruited from the Internal Medicine clinic, Qassim University. The patients were grouped into: 72 HTN without T2DM; 62 HTN with T2DM and 66 T2DM only. Full medical history, examination and biochemical assays were performed for all participants. Genomic DNA was isolated from blood lymphocytes of all subjects for detection of α2B-AR gene polymorphism by using polymerase chain reaction (PCR). The results found a significant association between D carriers genotype and HTN with T2DM cases (p < 0.05) as well as with T2DM-only cases, (p < 0.05) compared to control. Regardless of HTN status, only cases with HTN and T2DM as well as those with T2DM were significantly associated with the recessive model DD versus II+ID (p < 0.05). So, D carriers genotype was significantly associated with total cases of HTN and T2DM (p < 0.05) compared to controls. Our results suggested that there is a relationship between the α2B-AR I/D gene polymorphism and the risk for T2DM with or without HTN, but no such comparable relationship is evident with HTN-only cases among Saudi population in Qassim region.

高血压（HTN）和2型糖尿病（T2DM）是遗传和环境因素共同作用的常见多因素疾病。α2B 肾上腺素受体 (α2B-AR) 与胰岛素的分泌有关，并介导血管收缩，从而升高血压。本研究旨在确定沙特病例中 α2B-AR 基因多态性与 HTN 和 T2DM 之间的关联。从卡西姆大学内科诊所招募了来自沙特人口的​​ 200 例病例和 100 例健康对照。患者被分为： 72 例 HTN，无 T2DM；62 HTN 带 T2DM 和 66 T2DM 仅。对所有参与者进行了完整的病史、检查和生化检测。从所有受试者的血液淋巴细胞中分离基因组DNA，采用聚合酶链反应（PCR）检测α2B-AR基因多态性。结果发现， 与对照相比， D 携带者基因型和 HTN 与 T2DM 病例 ( p  < 0.05) 以及仅 T2DM 病例 ( p < 0.05) 之间存在显着相关性。无论 HTN 状态如何，只有 HTN 和 T2DM 病例以及 T2DM 病例与隐性模型 DD 与 II+ID 显着相关 ( p  < 0.05)。 因此，与对照组相比，D 携带者基因型与 HTN 和 T2DM 总病例显着相关 ( p < 0.05)。我们的结果表明，α2B-AR I/D 基因多态性与伴或不伴 HTN 的 T2DM 风险之间存在相关性，但在卡西姆地区的沙特人群中，仅使用 HTN 的病例不存在明显的可比关系。