Post-treatment outcome in canine glial tumours is described with a broad range of survival times between 2 and 28 months. After surgery or radiation therapy, the tumours may progress locally or spread within the central nervous system. It is unknown if tumour- or patient-specific factors influence prognosis. In humans, glioblastoma involving the subventricular zone has been found to recur distantly, with shortened time to progression and overall survival. We included 32 dogs irradiated for a presumptive primary glial brain tumour in this retrospective cohort study. Tumours were grouped relative to subventricular zone contact and overt ventricular invasion assessing pre-treatment magnetic resonance images. Median time to progression (TTP) for all cases was 534 days (95%CI, 310–758), with a significantly shorter TTP in dogs with lesions at the subventricular zone (median TTP, 260 vs. 687 days; p = .049). Tumours at the subventricular zone progressed more often (p = .001), and more likely as CNS-metastasis (52.9% vs. 13.3%, p = .028). Median overall survival (OS) was 489 days (95%CI, 147–831) and median tumour-specific survival 609 days (95%CI, 382–835). Involvement of the subventricular zone was significantly associated with a shorter tumour-specific survival (median, 306 vs. 719 days; p = .044). Glial tumours contacting the subventricular zone in dogs have a shorter tumour-specific survival and a higher rate of progression and CNS-metastasis. Despite local tumour control, metastasis must be considered and should prompt further treatment approaches.

中文翻译：

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用放射疗法治疗的犬推测的神经胶质脑瘤：接触脑室下区的肿瘤是否有较差的结果？

犬神经胶质瘤的治疗后结果被描述为具有 2 至 28 个月的广泛生存时间。手术或放射治疗后，肿瘤可能会局部进展或在中枢神经系统内扩散。目前尚不清楚肿瘤或患者特异性因素是否会影响预后。在人类中，已发现累及脑室下区的胶质母细胞瘤远处复发，进展时间和总生存期缩短。在这项回顾性队列研究中，我们纳入了 32 只因推定的原发性胶质脑肿瘤而接受放射治疗的狗。肿瘤根据脑室下区接触和明显的脑室侵犯进行分组，以评估治疗前的磁共振图像。所有病例的中位进展时间 (TTP) 为 534 天 (95%CI, 310–758),p  = .049）。脑室下区的肿瘤进展更频繁（p  = .001），更有可能是 CNS 转移（52.9% 对 13.3%，p  = .028）。中位总生存期 (OS) 为 489 天 (95%CI, 147-831)，中位肿瘤特异性生存期为 609 天 (95%CI, 382-835)。脑室下区受累与较短的肿瘤特异性生存期显着相关（中位数，306 天 vs. 719 天；p  = .044）。与狗脑室下区接触的神经胶质瘤具有较短的肿瘤特异性生存期和较高的进展率和中枢神经系统转移率。尽管局部肿瘤得到控制，但必须考虑转移，并应采取进一步的治疗方法。