Abstract

During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol (1) and neokotalanol (4), and related thiosugar sulfoniums, from the roots and stems of the genus Salacia plants [Celastraceae (Hippocrateaceae)] such as Salacia reticulata Wight, S. oblonga Wall., and S. chinensis L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus Salacia, from basic chemical and pharmacological research to their application and development as new functional food ingredients.

Graphic abstract

中文翻译：

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来自五层龙属植物的抗糖尿病活性硫糖锍、salacinol 和 neokotalanol 的综述

摘要

在我们从食物资源中表征用于预防和治疗生活方式相关疾病的功能性物质的研究过程中，我们从五层龙属的根和茎中分离出了活性成分，salacinol ( 1 ) 和 Neokotalanol ( 4 )，以及相关的硫糖锍。植物[Celastraceae (Hippocrateaceae)]，例如Salacia reticulata Wight、S. oblonga Wall.和S. chinensisL.，并观察了它们的抗糖尿病作用。这些植物材料传统上在阿育吠陀医学中用作糖尿病早期的特定药物，并在日本、美国和其他国家广泛用作预防肥胖和糖尿病的食品补充剂。在这里，我们回顾了我们对五层龙属植物抗糖尿病作用的研究，从基础化学和药理研究到它们作为新功能食品成分的应用和开发。

图形摘要