Background The prevalence and prognosis of post-acute stage SARS-CoV-2 infection fatigue symptoms remain largely unknown. Aims We performed a systematic review to evaluate the prevalence of fatigue in post-recovery from SARS-CoV-2 infection. Method Medline, Embase, PsycINFO, CINAHL, Web of Science, Scopus, trial registries, Cochrane Central Register of Controlled Trials and Google Scholar were searched for studies on fatigue in samples that recovered from PCR diagnosed COVID-19. Meta-analyses were conducted separately for each recruitment setting. Results We identified 39 studies with 8825 patients that recovered from COVID-19. Post-COVID-19 patients self-report of fatigue was higher compared to healthy controls (RR = 3.688, 95%CI [2.502, 5.436], p < 0.001). Over 50% of patients discharged from inpatient care reported symptoms of fatigue during the first (ER = 0.517, 95%CI [0.278, 0.749]) and second month following recovery (ER = 0.527, 95%CI [0.337, 0.709]). 10% of the community patients reported fatigue in the first month post-recovery. Patient setting moderated the association between COVID-19 recovery and fatigue symptoms (R2 = 0.12, p < 0.001). Female gender was associated with greater self-report of fatigue (OR =1.782, 95%CI [1.531, 2.870]). Patients recruited through social media had fatigue above 90% across multiple time points. Fatigue was highest in studies from Europe. Conclusion Fatigue is a symptom associated with functional challenges which could have economic and social impacts. Developing long-term planning for fatigue management amongst patients beyond acute stages of SARS-CoV-2 infection is essential to optimizing patient care and public health outcomes.

中文翻译：

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康复期或康复期 COVID-19 患者中与 COVID-19 相关的疲劳症状；系统评价和荟萃分析

背景 SARS-CoV-2 感染后急性期疲劳症状的患病率和预后在很大程度上仍然未知。目的 我们进行了一项系统评价，以评估从 SARS-CoV-2 感染恢复后的疲劳患病率。在 Medline、Embase、PsycINFO、CINAHL、Web of Science、Scopus、试验注册、Cochrane 对照试验中央注册和 Google Scholar 中搜索了关于从 PCR 诊断出的 COVID-19 中恢复的样本中疲劳的研究。对每个招募环境分别进行了荟萃分析。结果 我们确定了 39 项研究，共 8825 名从 COVID-19 中康复的患者。与健康对照相比，COVID-19 后患者自我报告的疲劳程度更高（RR = 3.688, 95% CI [2.502, 5.436]，p < 0.001）。超过 50% 的住院患者在康复后的第一个月 (ER = 0.517, 95%CI [0.278, 0.749]) 和第二个月 (ER = 0.527, 95%CI [0.337, 0.709]) 出现疲劳症状。10% 的社区患者在康复后的第一个月报告疲劳。患者环境调节了 COVID-19 恢复与疲劳症状之间的关联（R2 = 0.12，p < 0.001）。女性与更多的疲劳自我报告相关（OR = 1.782, 95% CI [1.531, 2.870]）。通过社交媒体招募的患者在多个时间点的疲劳度超过 90%。在欧洲的研究中，疲劳程度最高。结论 疲劳是与可能产生经济和社会影响的功能性挑战相关的症状。