Abstract

Fe₃O₄@SiO₂–Pr@L-proline magnetic nanoparticles were synthesized and their efficiency as nanocatalyst for the synthesis of new derivatives of bis dapsone derived dihydropyridines via one-pot three-component condensation reaction of various aromatic aldehydes, dimedone and dapsone in aqueous media was investigated. The products were characterized by ¹H NMR, ¹³C NMR, FT-IR and CHNS analysis. These bis-drugs present high antibacterial activities against both gram-negative (Pseudomonas aeruginosa and Escherichia coli) and gram-positive (Micrococcus luteus and Bacillus subtilis) bacteria, which are in general more sensitive to compounds with halogen or hydroxyl functional groups.

中文翻译：

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Fe 3 O 4 @SiO 2 –Pr @ L-脯氨酸合成的新的双-Dapsone衍生的二氢吡啶的合成，表征和抗菌活性的评价

摘要

合成了Fe ₃ O ₄ @SiO ₂ –Pr @ L-脯氨酸磁性纳米粒子，并通过各种芳香醛，二甲酮和氨苯砜的一锅三组分缩合反应，将其用作合成双氨苯砜衍生的二氢吡啶类新衍生物的纳米催化剂。在水性介质中进行了研究。产物通过¹ H NMR，¹³ C NMR，FT-IR和CHNS分析进行表征。这些双药对革兰氏阴性（铜绿假单胞菌和大肠杆菌）和革兰氏阳性（微球菌和枯草芽孢杆菌）均具有很高的抗菌活性。）细菌，通常对具有卤素或羟基官能团的化合物更敏感。