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Separation of Long-Lived Radionuclides on QMA Light Anion-Exchange Cartridge in Manufacture of Radiopharmaceutical Preparations Based on 18 F
Radiochemistry ( IF 0.9 ) Pub Date : 2021-04-26 , DOI: 10.1134/s1066362221020144
V. O. Krot , S. D. Brinkevich , D. I. Brinkevich , A. A. Ivanyukovich

Abstract

Sorption and elution on a QMA light anion-exchange cartridge of long-lived radionuclides formed in [18O]H2O under irradiation of a niobium target with Havar alloy input window on a Cyclone 18/9 HC cyclotron have been studied. It was shown that more than 90% of 51Cr and 7Be radionuclides from irradiated [18O]H2O is sorbed on the QMA light anion-exchange cartridge. 55,56, 57,58Co, 52,54Mn, and 57Ni radionuclides pass through the cartridge and are delivered into a flask with [18O]H2O for subsequent regeneration. It was found that about 30% of cobalt and manganese radioisotopes and also ~7% of chromium are present in the irradiated [18O]H2O in solid particles >5 μm in size. It was found that the main dose-providing chromium, manganese, cobalt, and beryllium radionuclides are hardly desorbed from QMA light in the elution of [18F]fluoride with a K2CO3 complex with cryptand [2.2.2] in an acetonitrile–water mixture, which provides a purification of these radionuclide impurities, with their amount reduced by a factor of 30–100. Nb, Ta, Re, and Tc radioisotopes are quantitatively sorbed on the anion-exchange cartridge and are mostly (up to 80% of the total activity) eluted together with [18F]fluoride into a reactor for synthesis. The observed fundamental aspects of the distribution of long-lived radionuclides are explained with consideration for their chemical forms of existence in aqueous solutions and the properties of the sorbents used.



中文翻译:

基于18 F的放射性药物制剂生产中QMA轻质阴离子交换柱上长寿命放射性核素的分离

摘要

研究了在铌靶上用哈弗合金输入窗在Cyclone 18/9 HC回旋加速器上辐照的铌靶上,在[ 18 O] H 2 O中形成的长寿命放射性核素的QMA轻型阴离子交换盒上的吸附和洗脱。结果表明,来自[ 18 O] H 2 O的51 Cr和7 Be放射性核素中有90%以上吸附在QMA轻型阴离子交换滤芯上。55,56,57,58钴,52,54 Mn和57倍的Ni的放射性核素穿过盒和被递送到烧瓶中与[ 18 O] H ^ 2O用于后续再生。已发现,经辐照的[ 18 O] H 2 O尺寸大于5μm的固体颗粒中存在约30%的钴和锰放射性同位素,以及约7%的铬。研究发现,在[ 18 F]氟化物与乙二胺与隐含钾[2.2.2]的K 2 CO 3络合物的洗脱中,主要提供剂量的铬,锰,钴和铍放射性核素几乎无法从QMA光中解吸。-水混合物,可纯化这些放射性核素杂质,其含量减少30-100倍。Nb,Ta,Re和Tc放射性同位素被定量吸附在阴离子交换柱上,并且大部分(占总活性的80%)与[18 F]氟化物进入反应器进行合成。考虑到长寿命放射性核素在水溶液中的化学形式和所用吸附剂的特性,对所观察到的长寿命放射性核素分布的基本方面进行了解释。

更新日期:2021-04-27
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