Anthracnose disease of sorghum is caused by Colletotrichum sublineola, a filamentous fungus. The genetic basis of resistance to anthracnose in sorghum is largely unclear, especially in Senegalese sorghum germplasm. In this study, 163 Senegalese sorghum accessions were evaluated for response to C. sublineola, and a genome-wide association study (GWAS) was performed to identify genetic variation associated with response to C. sublineola using 193,727 single nucleotide polymorphisms (SNPs) throughout the genome. Germplasm diversity analysis showed low genetic diversity and slow linkage disequilibrium (LD) decay among the Senegalese accessions. Phenotypic analysis resulted in relatively low differences to C. sublineola among the tested population. Genome-wide association study did not identify any significant association based on a strict threshold for the number of SNPs available. However, individual analysis of the top eight SNPs associated with relative susceptibility and resistance identified candidate genes that have been shown to play important roles in plant stress tolerance in previous studies. This study identifies sorghum genes whose annotated properties have known roles in host defense and thus identify them as candidates for use in breeding for resistance to anthracnose.

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塞内加尔高粱种质对德克萨斯炭疽病分离株反应的全基因组关联分析

高粱炭疽病是由丝状炭疽菌（Colletotrichum sublineola）引起的。高粱抗炭疽病的遗传基础在很大程度上尚不清楚，尤其是在塞内加尔高粱种质中。在这项研究中，评估了 163 个塞内加尔高粱种质对C 的响应。 sublineola，并进行了全基因组关联研究 (GWAS)，以使用整个基因组中的 193,727 个单核苷酸多态性 (SNP)来鉴定与对C. sublineola 的反应相关的遗传变异。种质多样性分析表明，塞内加尔种质之间的遗传多样性低，连锁不平衡（LD）衰减缓慢。表型分析导致与C. sublineola 的差异相对较低在受试人群中。基于可用 SNP 数量的严格阈值，全基因组关联研究未发现任何显着关联。然而，对与相对易感性和抗性相关的前 8 个 SNP 的个别分析确定了在先前研究中已被证明在植物胁迫耐受性中起重要作用的候选基因。这项研究确定了高粱基因，其注释特性在宿主防御中具有已知作用，因此将它们确定为用于抗炭疽病育种的候选基因。