Titanium implant success is compromised by microbial biofilms and aseptic loosening. This research aimed to develop robust multifunctional class II organic-inorganic hybrid coatings for implants with osteoconductive and antibacterial properties. 3-Glycidoxypropyltrimethoxysilane was coupled with organic polymer poly(ethylene) glycol-diamine (PEG-NH2) for integration into an inorganic sol backbone composed of tetraethoxysilane and calcium, which was sourced from newly synthesized calcium-2-ethoxyethoxide. Nuclear magnetic resonance and attenuated total reflectance Fourier transform infrared spectroscopy confirmed synthesis of precursors and the structure of coating constituents. Scanning electron microscopy and energy-dispersive X-ray spectroscopy (EDS) demonstrated homogenous coatings, micro-topographical surface features, and apatite-like ex vivo mineralization in simulated body fluid. Tensile adhesion testing demonstrated robust and highly adherent (15.1 ± 3.3 MPa) coatings on titanium substrates. Hybrid coatings imbedded with silver nanoparticles (nAg) significantly inhibited (P < 0.05) Staphylococcus aureus and Escherichia coli planktonic cultures and biofilm formation. These Si-Ca-PEG-nAg hybrid coatings for titanium implants offer robust multifunctional features.

钛植入物的成功受到微生物生物膜和无菌性松动的影响。这项研究旨在为具有骨传导和抗菌特性的植入物开发坚固耐用的多功能II类有机-无机杂化涂层。3-缩水甘油氧基丙基三甲氧基硅烷与有机聚合物聚乙二醇二胺（PEG-NH2）偶联，以整合到由四乙氧基硅烷和钙组成的无机溶胶骨架中，该骨架由新合成的2-乙氧基乙氧基钙获得。核磁共振和衰减的全反射傅里叶变换红外光谱证实了前驱体的合成和涂层成分的结构。扫描电子显微镜和能量色散X射线光谱（EDS）证明了涂层均匀，微观形貌表面特征，和模拟体液中的磷灰石样离体矿化。拉伸粘合力测试表明钛基材上的涂层坚固且高度粘合（15.1±3.3 MPa）。嵌入银纳米颗粒（nAg）的杂化涂层可显着抑制（P  <0.05）金黄色葡萄球菌和大肠杆菌浮游培养物和生物膜形成。这些用于钛植入物的Si-Ca-PEG-nAg杂化涂层具有强大的多功能特性。