The E6 genotypic variants of HPV 16 identified in lesions of women with cervical cancer (CC) in Southern of Mexico include the E-G350, AAa, AAc, E-C188/G350, and E-A176/G350, transcriptomic analysis cells transfected with those variants showed to induce differential expression of the host genes involved in the development of CC, the aim of this work was to understand how the over-expression of the E6 oncoprotein and its variants can induce molecular mechanisms that lead to more aggressive HPV 16 phenotypes in cervical cancer and which proteins could be associated with the process.

中文翻译：

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HPV 16 E6 癌蛋白变体对 C33A 细胞蛋白质组改变的影响。

在墨西哥南部的宫颈癌 (CC) 女性病变中发现的 HPV 16 的 E6 基因型变异包括 E-G350、AAa、AAc、E-C188/G350 和 E-A176/G350，转录组分析细胞转染了这些变体显示出诱导参与 CC 发展的宿主基因的差异表达，这项工作的目的是了解 E6 癌蛋白及其变体的过度表达如何诱导导致更具侵袭性的 HPV 16 表型的分子机制在宫颈癌中以及哪些蛋白质可能与该过程有关。