Colorectal cancer is currently the third leading cause of cancer-related deaths and recently, alternative splicing has risen as its important regulator and potential treatment target. In the present study, we analyzed gene expression of the MBNL family of regulators of alternative splicing in various stages of colorectal cancer development, together with the MBNL-target splicing events in FOXP1 and EPB41L3 genes and tumor-related CD44 variants.

中文翻译：

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改变的 MBNL 家族选择性剪接因子在结肠直肠癌中的表达。

结直肠癌目前是癌症相关死亡的第三大原因，最近，选择性剪接已成为其重要的调节剂和潜在的治疗目标。在本研究中，我们分析了 MBNL 家族选择性剪接调节因子在结直肠癌发展的各个阶段的基因表达，以及 FOXP1 和 EPB41L3 基因和肿瘤相关 CD44 变体中的 MBNL 靶标剪接事件。