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Potential Molecular Cross Talk Among CCR5 Pathway Predicts Regorafenib Responsiveness in Metastatic Colorectal Cancer Patients.
Cancer Genomics & Proteomics ( IF 2.6 ) Pub Date : 2021-4-25 , DOI: 10.21873/cgp.20262
Mitsukuni Suenaga 1, 2, 3 , W U Zhang 4 , Tetsuo Mashima 5 , Marta Schirripa 4 , Shu Cao 6 , Satoshi Okazaki 4 , Martin D Berger 4 , Yuji Miyamoto 4 , Afsaneh Barzi 4 , Toshiharu Yamaguchi 2 , Heinz-Josef Lenz 4
Affiliation  

Genetic variants in the CCL5/CCR5 pathway have been shown to predict regorafenib efficacy in patients with metastatic colorectal cancer (mCRC). This study investigated the biological role of CCL4 and CCL3 gene polymorphisms in patients with refractory mCRC treated using regorafenib.

中文翻译:

CCR5 通路之间潜在的分子串扰预测转移性结直肠癌患者对瑞戈非尼的反应。

CCL5/CCR5 通路中的遗传变异已被证明可以预测瑞戈非尼在转移性结直肠癌 (mCRC) 患者中的疗效。本研究调查了 CCL4 和 CCL3 基因多态性在使用瑞戈非尼治疗的难治性 mCRC 患者中的生物学作用。
更新日期:2021-04-27
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