Meningiomas are the most commonly diagnosed benign intracranial adult tumors. Subsets of meningiomas that present with extensive invasion into surrounding brain areas have high recurrence rates, resulting in difficulties for complete resection, substantially increased mortality of patients, and are therapeutically challenging for neurosurgeons. Exciting new data have provided insights into the understanding of the molecular machinery of invasion. Moreover, clinical trials for several novel approaches have been launched. Here, we will highlight the mechanisms which govern brain invasion and new promising therapeutic approaches for brain-invasive meningiomas, including pharmacological approaches targeting three major aspects of tumor cell invasion: extracellular matrix degradation, cell adhesion, and growth factors, as well as other innovative treatments such as immunotherapy, hormone therapy, Tumor Treating Fields, and biodegradable copolymers (wafers), impregnated chemotherapy. Those ongoing studies can offer more diversified possibilities of potential treatments for brain-invasive meningiomas, and help to increase the survival benefits for patients.

脑膜瘤是最常见的良性颅内成人肿瘤。脑膜瘤亚群广泛侵犯周围脑区，复发率高，导致难以完全切除，患者死亡率显着增加，对神经外科医生来说具有治疗挑战性。令人兴奋的新数据为理解入侵的分子机制提供了见解。此外，已经启动了几种新方法的临床试验。在这里，我们将重点介绍控制脑侵袭的机制和脑侵袭性脑膜瘤的新治疗方法，包括针对肿瘤细胞侵袭三个主要方面的药理学方法：细胞外基质降解、细胞粘附和生长因子，以及其他创新疗法，如免疫疗法、激素疗法、肿瘤治疗领域和可生物降解的共聚物（晶圆）、浸渍化学疗法。这些正在进行的研究可以为脑浸润性脑膜瘤的潜在治疗提供更多样化的可能性，并有助于提高患者的生存率。