Does sodium oxybate inhibit brain dopamine release in humans? An exploratory neuroimaging study,Human Psychopharmacology: Clinical and Experimental

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Does sodium oxybate inhibit brain dopamine release in humans? An exploratory neuroimaging study
Human Psychopharmacology: Clinical and Experimental ( IF 1.672 ) Pub Date : 2021-04-26 , DOI: 10.1002/hup.2791
Stephen J Kish ₁ , Gerald O'Leary ₂ , Mortimer Mamelak ₃ , Tina McCluskey ₄ , Jerry J Warsh ₅ , Colin Shapiro ₆ , Robert Bies ₇ , Yifan Yu ₇ , Bruce Pollock ₈ , Junchao Tong ₉ , Isabelle Boileau ₁₀

Affiliation

Centre for Addiction and Mental Health (CAMH), Human Brain Lab, Toronto, ON, Canada.
Department of Anesthesia and Pain Management, University Health Network - Toronto General Hospital, Toronto, ON, Canada.
Department of Psychiatry, Baycrest Hospital, Toronto, ON, Canada.
Centre for Addiction and Mental Health (CAMH), Brain Health Imaging Centre, Toronto, ON, Canada.
Department of Neuroscience, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Department of Ophthalmology, University of Toronto, Toronto, ON, Canada.
Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.
Centre for Addiction and Mental Health (CAMH), Campbell Family Mental Health Research Institute, Toronto, ON, Canada.
Centre for Addiction and Mental Health (CAMH), Preclinical Imaging, Brain Health Imaging Centre, Toronto, ON, Canada.
Centre for Addiction and Mental Health (CAMH), Addiction Imaging Research Group, Toronto, ON, Canada.

To establish in an exploratory neuroimaging study whether γ-hydroxybutyrate (sodium oxybate [SO]), a sedative, anti-narcoleptic drug with abuse potential, transiently inhibits striatal dopamine release in the human.

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