Coxiella burnetii causes Q fever in individuals exposed to infected ruminants. Vaccination in 3−4-month-old goats, has been reported to result in significantly greater reduction in C. burnetii shedding compared to goats vaccinated one month before breeding, the most commonly used strategy of controlling Q fever on infected intensively-managed herds. It is possible that an even greater reduction in the number of animals shedding C. burnetii could be achieved if vaccination were administered shortly after protection from colostrum antibodies wanes and animals become susceptible to infection with C. burnetii. This study aimed to evaluate the immunogenicity and safety of a formaldehyde-inactivated phase 1 C. burnetii vaccine in 8-week-old goats. Two injections, four weeks apart, elicited specific IgM and IgG responses in all vaccinated goats (n = 6), while no antibodies were detected in two control groups (n = 12). Swelling at the site of inoculation was observed in all the vaccinated and in 10/11 of the placebo-treated goats but receded after 3 weeks. Weight change and rectal temperatures were also comparable between vaccinated and control goats. The data indicated that this vaccine could be suitable for immunising 8-week-old goats, although further trials to determine level of protection against challenge are required.

Coxiella burnetii在暴露于受感染反刍动物的个体中引起 Q 热。据报道，与在繁殖前 1 个月接种疫苗的山羊相比，在 3-4 个月大的山羊中接种疫苗可显着减少C.burnetii 的脱落，这是控制受感染的集中管理牛群的 Q 热的最常用策略。如果在对初乳抗体的保护减弱并且动物变得容易感染C.burnetii后立即接种疫苗，则有可能进一步减少C.burnetii的动物数量。本研究旨在评估甲醛灭活的 1 期C.burnetii的免疫原性和安全性8 周龄山羊接种疫苗。两次注射，间隔 4 周，在所有接种疫苗的山羊 (n = 6) 中引发特异性 IgM 和 IgG 反应，而在两个对照组 (n = 12) 中未检测到抗体。在所有接种疫苗的山羊和 10/11 的安慰剂治疗山羊中观察到接种部位肿胀，但在 3 周后消退。接种山羊和对照山羊的体重变化和直肠温度也相当。数据表明，这种疫苗可能适用于对 8 周大的山羊进行免疫接种，但需要进一步试验以确定抵御攻击的保护水平。