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Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice
Journal of Neuroendocrinology ( IF 3.3 ) Pub Date : 2021-04-24 , DOI: 10.1111/jne.12972 Betina B Nair 1 , Zin Khant Aung 1 , Robert Porteous 1 , Melanie Prescott 1 , Kelly A Glendining 1 , Danielle E Jenkins 1 , Rachael A Augustine 1 , Mauro S B Silva 1 , Siew H Yip 1 , Gregory T Bouwer 1 , Colin H Brown 1 , Christine L Jasoni 1 , Rebecca E Campbell 1 , Stephen J Bunn 1 , Greg M Anderson 1 , David R Grattan 1 , Allan E Herbison 1 , Karl J Iremonger 1
Journal of Neuroendocrinology ( IF 3.3 ) Pub Date : 2021-04-24 , DOI: 10.1111/jne.12972 Betina B Nair 1 , Zin Khant Aung 1 , Robert Porteous 1 , Melanie Prescott 1 , Kelly A Glendining 1 , Danielle E Jenkins 1 , Rachael A Augustine 1 , Mauro S B Silva 1 , Siew H Yip 1 , Gregory T Bouwer 1 , Colin H Brown 1 , Christine L Jasoni 1 , Rebecca E Campbell 1 , Stephen J Bunn 1 , Greg M Anderson 1 , David R Grattan 1 , Allan E Herbison 1 , Karl J Iremonger 1
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Chronic stress exerts multiple negative effects on the physiology and health of an individual. In the present study, we examined hypothalamic, pituitary and endocrine responses to 14 days of chronic variable stress (CVS) in male and female C57BL/6J mice. In both sexes, CVS induced a significant decrease in body weight and enhanced the acute corticosterone stress response, which was accompanied by a reduction in thymus weight only in females. However, single-point blood measurements of basal prolactin, thyroid-stimulating hormone, luteinising hormone, growth hormone and corticosterone levels taken at the end of the CVS were not different from those of controls. Similarly, pituitary mRNA expression of Fshb, Lhb, Prl and Gh was unchanged by CVS, although Pomc and Tsh were significantly elevated. Within the adrenal medulla, mRNA for Th, Vip and Gal were elevated following CVS. Avp transcript levels within the paraventricular nucleus of the hypothalamus were increased by CVS; however, levels of Gnrh1, Crh, Oxt, Sst, Trh, Ghrh, Th and Kiss1 remained unchanged. Oestrous cycles were lengthened slightly by CVS and ovarian histology revealed a reduction in the number of preovulatory follicles and corpora lutea. Taken together, these observations indicate that 14 days of CVS induces an up-regulation of the neuroendocrine stress axis and creates a mild disruption of female reproductive function. However, the lack of changes in other neuroendocrine axes controlling anterior and posterior pituitary secretion suggest that most neuroendocrine axes are relatively resilient to CVS.
中文翻译：
慢性可变压力对雄性和雌性 C57BL/6J 小鼠下丘脑和垂体神经内分泌的影响
慢性压力会对个人的生理和健康产生多重负面影响。在本研究中，我们检查了雄性和雌性 C57BL/6J 小鼠对 14 天慢性可变压力 (CVS) 的下丘脑、垂体和内分泌反应。在两性中，CVS 均导致体重显着下降并增强了急性皮质酮应激反应，仅在女性中伴随着胸腺重量的减少。然而，在 CVS 结束时进行的基础催乳素、促甲状腺激素、促黄体生成素、生长激素和皮质酮水平的单点血液测量与对照组没有差异。同样， Fshb、Lhb、Prl和Gh的垂体 mRNA 表达CVS 没有改变，尽管Pomc和Tsh显着升高。在肾上腺髓质内，Th、Vip和Gal的 mRNA 在 CVS 后升高。CVS 增加了下丘脑室旁核内的Avp转录水平；然而，Gnrh1、Crh、Oxt、 Sst、Trh、Ghrh、Th和Kiss1 的水平保持不变。CVS 稍微延长了发情周期，卵巢组织学显示排卵前卵泡和黄体数量减少。总之，这些观察结果表明，14 天的 CVS 诱导神经内分泌应激轴的上调，并对女性生殖功能造成轻微破坏。然而，控制垂体前叶和后叶分泌的其他神经内分泌轴缺乏变化表明大多数神经内分泌轴对 CVS 具有相对弹性。
更新日期：2021-05-25
中文翻译：
慢性可变压力对雄性和雌性 C57BL/6J 小鼠下丘脑和垂体神经内分泌的影响
慢性压力会对个人的生理和健康产生多重负面影响。在本研究中，我们检查了雄性和雌性 C57BL/6J 小鼠对 14 天慢性可变压力 (CVS) 的下丘脑、垂体和内分泌反应。在两性中，CVS 均导致体重显着下降并增强了急性皮质酮应激反应，仅在女性中伴随着胸腺重量的减少。然而，在 CVS 结束时进行的基础催乳素、促甲状腺激素、促黄体生成素、生长激素和皮质酮水平的单点血液测量与对照组没有差异。同样， Fshb、Lhb、Prl和Gh的垂体 mRNA 表达CVS 没有改变，尽管Pomc和Tsh显着升高。在肾上腺髓质内，Th、Vip和Gal的 mRNA 在 CVS 后升高。CVS 增加了下丘脑室旁核内的Avp转录水平；然而，Gnrh1、Crh、Oxt、 Sst、Trh、Ghrh、Th和Kiss1 的水平保持不变。CVS 稍微延长了发情周期，卵巢组织学显示排卵前卵泡和黄体数量减少。总之，这些观察结果表明，14 天的 CVS 诱导神经内分泌应激轴的上调，并对女性生殖功能造成轻微破坏。然而，控制垂体前叶和后叶分泌的其他神经内分泌轴缺乏变化表明大多数神经内分泌轴对 CVS 具有相对弹性。
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