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Prelimbic prefrontal cortical encoding of reward predictive cues
SYNAPSE ( IF 1.6 ) Pub Date : 2021-04-24 , DOI: 10.1002/syn.22202 Mitchell G Spring 1 , Karan R Soni 1 , Daniel S Wheeler 1 , Robert A Wheeler 1
SYNAPSE ( IF 1.6 ) Pub Date : 2021-04-24 , DOI: 10.1002/syn.22202 Mitchell G Spring 1 , Karan R Soni 1 , Daniel S Wheeler 1 , Robert A Wheeler 1
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Animals appoint incentive value and learn to approach otherwise behaviorally inert stimuli if these stimuli come to predict the delivery of reward. Interestingly, this adaptive Pavlovian learning process has been implicated in behavioral control disorders, such as drug addiction. One brain region implicated in directing conditioned approach behavior is the prelimbic region of the prefrontal cortex. The present study employed in vivo electrophysiology in the prelimbic cortex to characterize the distribution of neural responses to the presence of a cue that had acquired incentive value after being associated with a primary reward. Male rats were trained in a Pavlovian autoshaping task in which a lever was presented prior to reward delivery. Following repeated pairings of lever availability and reward delivery, rats pressed the lever even though reward delivery was not contingent on any interaction with the lever. Neurons in the prelimbic cortex selectively encoded the presentation of the reward-predicting lever. Although the response was heterogeneous, most responsive neurons decreased their firing rate in response to the presence of the lever. These findings characterize the varied responses of prelimbic cortical neurons to reward cues and are consistent with evidence that the role of the prelimbic cortex in reward learning depends on the downstream target.
中文翻译：
奖励预测线索的前额叶皮层编码
如果这些刺激来预测奖励的传递，动物会指定激励价值并学会接近其他行为惰性的刺激。有趣的是，这种适应性巴甫洛夫学习过程与行为控制障碍有关，例如吸毒成瘾。与指导条件性接近行为有关的一个大脑区域是前额叶皮层的前边缘区域。本研究在前肢皮层中采用体内电生理学来表征神经反应的分布，以表征在与初级奖励相关联后获得激励价值的线索的存在。雄性大鼠接受了巴甫洛夫自动成形任务的训练，其中在奖励交付之前提供了一个杠杆。在杠杆可用性和奖励交付的反复配对之后，即使奖励交付不取决于与杠杆的任何交互，老鼠也会按下杠杆。前肢皮层中的神经元选择性地编码了奖励预测杠杆的呈现。尽管反应是异质的，但大多数反应性神经元响应杠杆的存在而降低了它们的放电率。这些发现表征了前肢皮质神经元对奖励线索的不同反应，并且与前肢皮质在奖励学习中的作用取决于下游目标的证据一致。
更新日期：2021-06-30
中文翻译：
奖励预测线索的前额叶皮层编码
如果这些刺激来预测奖励的传递，动物会指定激励价值并学会接近其他行为惰性的刺激。有趣的是，这种适应性巴甫洛夫学习过程与行为控制障碍有关，例如吸毒成瘾。与指导条件性接近行为有关的一个大脑区域是前额叶皮层的前边缘区域。本研究在前肢皮层中采用体内电生理学来表征神经反应的分布，以表征在与初级奖励相关联后获得激励价值的线索的存在。雄性大鼠接受了巴甫洛夫自动成形任务的训练，其中在奖励交付之前提供了一个杠杆。在杠杆可用性和奖励交付的反复配对之后，即使奖励交付不取决于与杠杆的任何交互，老鼠也会按下杠杆。前肢皮层中的神经元选择性地编码了奖励预测杠杆的呈现。尽管反应是异质的，但大多数反应性神经元响应杠杆的存在而降低了它们的放电率。这些发现表征了前肢皮质神经元对奖励线索的不同反应，并且与前肢皮质在奖励学习中的作用取决于下游目标的证据一致。
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