Laser speckle contrast imaging has been widely used for quantifying blood perfusion. In this letter, we propose a rapid, wide-field laser speckle angiography technique for noninvasive imaging of retinal and choroidal vessels. The field of view (FOV) reaches ∼50^∘ while the acquisition time was less than 1 s. Larger FOV (∼90^∘) can be further improved by mosaicking. The results were comparatively studied with optical coherence tomography angiography and fundus fluorescence angiography. The low-cost technology can obtain wide-field fundus vascular and perfusion images less than 1 s. This technology is more suitable for optic disc and choroidal vasculature imaging. In addition, blood flow dynamic information such as pulsation can be provided by this technique.

激光散斑对比成像已广泛用于量化血液灌注。在这封信中，我们提出了一种快速、广域激光散斑血管造影技术，用于视网膜和脉络膜血管的无创成像。视野 (FOV) 达到 ~50 ^∘，而采集时间小于 1 秒。更大的 FOV (∼90 ^∘ ) 可以通过镶嵌进一步改善。结果与光学相干断层扫描血管造影和眼底荧光血管造影进行了比较研究。低成本的技术可以在1秒内获得宽视野的眼底血管和灌注图像。该技术更适用于视盘和脉络膜血管成像。此外，该技术还可以提供脉动等血流动态信息。