Kinesin is a two-headed biological molecular motor that can walk processively on microtubule via consumption of ATP molecules. The central issue for the molecular motor is how the chemical energy released from ATP hydrolysis is converted to the kinetic energy of the mechanical motion, namely the mechanism of chemomechanical coupling. To address the issue, diverse experimental methods have been employed and a lot of models have been proposed. This review focuses on the proposed models as well as the qualitative and quantitative comparisons between the results derived from the models and those from the structural, biochemical and single-molecule experimental studies.

中文翻译：

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深入了解驱动蛋白分子马达的化学机械耦合机制

驱动蛋白是一种双头生物分子马达，可以通过消耗 ATP 分子在微管上进行性行走。分子马达的核心问题是ATP水解释放的化学能如何转化为机械运动的动能，即化学机械耦合机制。为了解决这个问题，已经采用了多种实验方法并提出了许多模型。本综述重点关注所提出的模型，以及模型结果与结构、生化和单分子实验研究结果之间的定性和定量比较。