Integration of evidence across human and model organism studies: A meeting report,Genes, Brain and Behavior

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Integration of evidence across human and model organism studies: A meeting report
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2021-04-23 , DOI: 10.1111/gbb.12738
Rohan H C Palmer ₁ , Emma C Johnson ₂ , Hyejung Won ₃ , Renato Polimanti ₄ , Manav Kapoor ₅ , Apurva Chitre ₆ , Molly A Bogue ₇ , Chelsie E Benca-Bachman ₁ , Clarissa C Parker ₈ , Anurag Verma ₉ , Timothy Reynolds ₇ , Jason Ernst ₁₀ , Michael Bray ₂ , Soo Bin Kwon ₁₀ , Dongbing Lai ₁₁ , Bryan C Quach ₁₂ , Nathan C Gaddis ₁₂ , Laura Saba ₁₃ , Hao Chen ₁₄ , Michael Hawrylycz ₁₅ , Shan Zhang ₁₆ , Yuan Zhou ₁₇ , Spencer Mahaffey ₁₈ , Christian Fischer ₁₉ , Sandra Sanchez-Roige ₆ , Anita Bandrowski ₂₀ , Qing Lu ₁₇ , Li Shen ₅ , Vivek Philip ₇ , Joel Gelernter ₄ , Laura J Bierut ₂ , Dana B Hancock ₁₂ , Howard J Edenberg _{11,

21} , Eric O Johnson ₁₂ , Eric J Nestler ₅ , Peter B Barr ₂₂ , Pjotr Prins ₁₉ , Desmond J Smith ₂₃ , Schahram Akbarian ₂₄ , Thorgeir Thorgeirsson ₂₅ , Dave Walton ₇ , Erich Baker ₂₆ , Daniel Jacobson _{27,

28} , Abraham A Palmer _{6,

29} , Michael Miles ₃₀ , Elissa J Chesler ₇ , Jake Emerson ₇ , Arpana Agrawal ₂ , Maryann Martone ₂₀ , Robert W Williams ₁₉

Affiliation

Behavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, Atlanta, Georgia, USA.
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Genetics and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA.
Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
The Jackson Laboratory, Bar Harbor, Maine, USA.
Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
Biomedical and Translational Informatics Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, USA.
Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Department of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Allen Institute, Seattle, Washington, USA.
Department of Statistics and Probability, Michigan State University, East Lansing, Michigan, USA.
Department of Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Aurora, Colorado, USA.
Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Department of Neuroscience, University of California, San Diego, La Jolla, California, USA.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Friedman Brain Institute and Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
deCODE Genetics/Amgen Inc., Reykjavik, Iceland.
Department of Computer Science, Baylor University, Waco, Texas, USA.
Computational and Predictive Biology, Biosciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Department of Psychology, University of Tennessee Knoxville, Knoxville, Tennessee, USA.
Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA.
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.

The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration—particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs.

中文翻译：

人类和模式生物研究证据的整合：会议报告

国家药物滥用研究所和橡树岭国家实验室生物科学研究所联合主办了一次会议，与会者包括在物质使用障碍 (SUD)、计算生物学和 FAIR（可查找性、可访问性、互操作性、和可重用性）数据共享。会议的目标是讨论和评估更好的策略，以整合人类和模型生物体的遗传、表观遗传和组学数据，以实现对 SUD 更深入的机制洞察。具体主题包括 (a) 评估物质使用遗传学和基因组学研究的现状以及基本差距，(b) 确定跨物种和数据类型整合和共享的机遇和挑战，(c) 确定当前用于整合物质使用遗传学和基因组学研究的工具和资源。遗传、表观遗传和表型数据，(d) 讨论与数据集成相关的步骤和障碍，(e) 概述未来支持更有效合作的步骤，特别是动物模型研究团体与人类遗传学和临床研究团队之间的合作。本综述总结了这一催化讨论的关键方面，重点关注 SUD 资源和知识方面的新机遇和差距。

更新日期：2021-04-23

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