Abstract

Two new polyketides, palitantins B and C (1 and 2), along with one known related compound (+)-palitantin (3) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compound 3 showed potent PTP1B inhibitory activity with an IC₅₀ value of 7.9 μM (ursolic acid as positive control, IC₅₀ = 8.3 μM).

中文翻译：

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来自南极真菌 Geomyces sp. 的帕利坦丁衍生物。3-1

摘要

从南极真菌Geomyces sp.的培养物中获得了两种新的聚酮化合物 palitantins B 和 C（1和2），以及一种已知的相关化合物 (+)-palitantin ( 3 )。3-1。通过对 HRESIMS、NMR、CD 和 ECD 数据的详细分析，阐明了新化合物的结构。化合物3显示出有效的PTP1B抑制活性，IC ₅₀值为7.9  μ M（熊果酸作为阳性对照，IC ₅₀ = 8.3  μ M）。