Background and Aims. Due to the difficulty in clinical staging, a simple and feasible perioperative assessment approach for guiding personalized neoadjuvant chemotherapy (NAC) is lacking. We investigated the clinical value of NAC in advanced gastric carcinoma (GC) and the concordance between perioperative imaging and postoperative pathological assessments. Methods. This study included 62 patients with advanced GC who received NAC between January 2012 and December 2018. The preoperative and postoperative T stages, postoperative pathological tumor regression grade (TRG), and changes in computed tomography (CT) values after NAC were assessed. Follow-ups were conducted to obtain the median survival time (MST), and Kaplan–Meier survival curves were plotted. Results. The T stages significantly differed between before and after NAC (). The MST of patients in the TRG0 group was significantly different from that of patients in the TRG1+2 and TRG3 groups (). The percentages of positive lymph nodes were 0%, 24.17%, and 27.64% in the TRG0, TRG1+2, and TRG3 groups, respectively. TRG was correlated with changes in CT values before and after NAC, and the extent of change was associated with patient prognosis. Conclusions. Perioperative imaging can be used to assess the short-term effectiveness of NAC for patients with GC.

中文翻译：

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胃癌新辅助化疗的临床疗效及围手术期影像学评估参数探讨


背景和目标。由于临床分期的困难，缺乏简单可行的围手术期评估方法来指导个性化新辅助化疗（NAC）。我们研究了 NAC 在晚期胃癌（GC）中的临床价值以及围手术期影像学与术后病理评估之间的一致性。方法。本研究纳入了2012年1月至2018年12月期间接受NAC的62例晚期GC患者。评估了术前和术后T分期、术后病理肿瘤消退等级（TRG）以及NAC后计算机断层扫描（CT）值的变化。进行随访以获得中位生存时间（MST），并绘制Kaplan-Meier生存曲线。结果。 NAC前后T阶段有显着差异（ ）。 TRG0组患者的MST与TRG1+2组和TRG3组患者的MST有显着差异（）。 TRG0、TRG1+2、TRG3组淋巴结阳性率分别为0%、24.17%、27.64%。 TRG与NAC前后CT值的变化相关，变化程度与患者预后相关。结论。 围手术期影像学检查可用于评估 NAC 对 GC 患者的短期疗效。