Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2021-04-24 , DOI: 10.1007/s13659-021-00307-y Jian-Jun Zhao 1, 2 , Song-Yu Li 1, 2 , Fan Xia 1 , Ya-Li Hu 1, 2 , Yin Nian 1 , Gang Xu 1
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Saldigones A–C (1, 3, 4), three new isoprenylated flavonoids with diverse flavanone, pterocarpan, and isoflavanone architectures, were characterized from the roots of Salvia digitaloides, together with a known isoprenylated flavanone (2). Notably, it’s the first report of isoprenylated flavonoids from Salvia species. The structures of these isolates were elucidated by extensive spectroscopic analysis. All of the compounds were evaluated for their activities on Cav3.1 low voltage-gated Ca2+ channel (LVGCC), of which 2 strongly and dose-dependently inhibited Cav3.1 peak current.
Graphic Abstract
中文翻译：
异戊二烯化黄酮类化合物，作为来自鼠尾草的 Ca v 3.1 低压门控 Ca 2+ 通道抑制剂
Saldigones A–C ( 1 , 3 , 4 ) 是三种新的异戊二烯基黄酮类化合物，具有不同的黄烷酮、紫檀素和异黄酮结构，其特征来自于洋地黄鼠尾草的根部，以及已知的异戊二烯基黄烷酮 ( 2 )。值得注意的是，这是来自鼠尾草属异戊二烯化黄酮类化合物的首次报道。通过广泛的光谱分析阐明了这些分离物的结构。评估了所有化合物对 Ca v 3.1 低电压门控 Ca 2+通道 (LVGCC) 的活性，其中2 种化合物强烈且剂量依赖性地抑制 Ca v 3.1 峰值电流。
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