Acetaminophen (paracetamol, APAP) is a major component of Tylenol, Penzal Q, and Panpyrin, and is the most commonly used antipyretic analgesic in children. The conventional oral drug delivery systems of APAP are pills and tablets. However alternative drug delivery methods are desirable in case of pediatric or geriatric patients, especially for drugs like APAP that must be taken in large doses at once. Another requirement for a good drug delivery system is the rapid dissolution to ensure a rapid therapeutic action as pain reliever. In this study Acetaminophen (paracetamol, APAP) was encapsulated in a water-soluble polymer. After the preparation of the solid dispersion by encapsulating acetaminophen in polyvinylpyrroli-done, the resultant granules were used in three formulations: tablets, chewable tablets, and oral dissolving films (ODF). Solid dispersions and prepared formulations were evaluated by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffractometer (XRD), and universal tensile machine (UTM), and the release behavior was compared. As a result, it was confirmed that the oral dissolving films can be taken easily because it has the advantages of both tablet and liquid dosage form accurate dosage, easy administration, easy swallowing, and fast bioavailability. Furthermore, the drug absorption rate can be effectively increased by changing the formulation.

对乙酰氨基酚（扑热息痛，APAP）是泰诺尔，彭赞尔Q和Panpyrin的主要成分，是儿童中最常用的解热镇痛药。APAP的常规口服药物输送系统是丸剂和片剂。但是，对于儿科或老年患者，特别是对于必须立即大剂量服用的APAP之类的药物，则需要替代的药物递送方法。良好的药物输送系统的另一个要求是快速溶解，以确保作为止痛药具有快速的治疗作用。在这项研究中，对乙酰氨基酚（扑热息痛，APAP）被封装在水溶性聚合物中。通过将对乙酰氨基酚封装在聚乙烯吡咯烷酮中制备固体分散体后，将所得颗粒用于三种制剂：片剂，可咀嚼片剂和口服溶解膜（ODF）。通过傅立叶变换红外光谱（FTIR），差示扫描量热法（DSC），X射线衍射仪（XRD）和通用拉伸机（UTM）对固体分散体和制备的制剂进行了评估，并比较了其释放性能。结果，证实了口服溶解膜易于服用，因为它具有片剂和液体剂型精确剂量，易于施用，易于吞咽和快速生物利用度的优点。此外，通过改变配方可以有效地提高药物吸收率。已经证实，由于其具有片剂和液体剂型精确剂量，易于给药，易于吞咽和快速生物利用度的优点，因此可以容易地服用口服溶解膜。此外，通过改变配方可以有效地提高药物吸收率。已经证实，由于其具有片剂和液体剂型精确剂量，易于给药，易于吞咽和快速生物利用度的优点，因此可以容易地服用口服溶解膜。此外，通过改变配方可以有效地提高药物吸收率。