Single atom catalysts (SACs) have attracted great attention as promising catalysts that integrate the benefits of both heterogeneous and homogeneous catalysts. SACs exhibit unique properties that are otherwise difficult to achieve, such as high atom utilization efficiency, unprecedentedly high catalytic activity and selectivity. However, it still remains a great challenge to prepare stable SACs without particle aggregation and sintering. Among the various fabrication methods for SACs, metal-organic framework (MOF)-derived synthesis routes have shown great potential by taking advantage of MOFs’ high structural/chemical tunability, large surface area and high porosity. In this review, the synthesis strategies for MOF-derived SACs are comprehensively summarized and classified into five classes, metal node modification, ligand modification, guest encapsulation, migration and trapping, and others. The current challenges and future opportunities of MOF-derived SACs are further discussed. This review will be useful for the rational design of MOF-derived SACs for various catalytic reactions.

单原子催化剂（SAC）作为有前途的催化剂吸引了广泛的关注，该催化剂兼具了非均相催化剂和均相催化剂的优点。SAC具有独特的特性，这些特性否则很难实现，例如高的原子利用效率，空前的高催化活性和选择性。然而，在没有颗粒聚集和烧结的情况下制备稳定的SAC仍然是一个巨大的挑战。在SAC的各种制造方法中，金属有机骨架（MOF）衍生的合成路线通过利用MOF的高结构/化学可调性，大表面积和高孔隙率而显示出巨大潜力。在这篇综述中，对MOF衍生的SAC的合成策略进行了概括总结，并分为五类，金属节点修饰，配体修饰，来宾封装，迁移和陷阱等。MOF衍生的SAC的当前挑战和未来机会将进一步讨论。这项审查将有助于合理设计MOF衍生的SAC用于各种催化反应。