Amyloidosis is a concept that implicates disorders and complications that are due to abnormal protein accumulation in different cells and tissues. Protein aggregation-associated diseases are classified according to the type of aggregates and deposition sites, such as neurodegenerative disorders and type 2 diabetes mellitus. Polyphenolic phytochemicals such as curcumin and its derivatives have anti-amyloid effects both in vitro and in animal models; however, the underlying mechanisms are not understood. In this review, we summarized possible mechanisms by which curcumin could interfere with self-assembly processes and reduce amyloid aggregation in amyloidosis. Furthermore, we discuss clinical trials in which curcumin is used as a therapeutic agent for the treatment of diseases linking to protein aggregates.

中文翻译：

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姜黄素：一种具有强大功能的小分子，可对抗神经退行性疾病和 2 型糖尿病中的淀粉样蛋白聚集

淀粉样变性是一个概念，它涉及由不同细胞和组织中异常蛋白质积累引起的疾病和并发症。蛋白质聚集相关疾病根据聚集体的类型和沉积部位进行分类，例如神经退行性疾病和 2 型糖尿病。姜黄素及其衍生物等多酚类植物化学物质在体外和动物模型中均具有抗淀粉样蛋白作用；然而，潜在的机制尚不清楚。在这篇综述中，我们总结了姜黄素干扰自组装过程并减少淀粉样变性中淀粉样蛋白聚集的可能机制。此外，我们讨论了将姜黄素用作治疗与蛋白质聚集体有关的疾病的治疗剂的临床试验。