Hispidin is a secondary metabolite with pharmacological properties that is produced by the medicinal mushroom Phellinus linteus. In this study, we evaluated the effect of metal ion addition to grain media while determining the optimal illumination and temperature conditions for hispidin production in P. linteus 03 using solid-state fermentation. Six metal ions were added to these media and P. linteus 03 grown in these media were for hispidin production under optimal incubation temperature and illumination conditions. The highest yield and specific productivity of hispidin, and total hispidin content were achieved at 25 °C in a dark environment which was maintained throughout the entire fermentation period for brown rice and pearl barley media. Addition of Zn²⁺ ions to brown rice medium resulted in the highest yield and specific productivity of hispidin and total hispidin content at 6 weeks of fermentation; these were 2.53-, 2.62-, and 2.43-fold, respectively higher than those observed in the control. This study shows that hispidin production by P. linteus 03 can be enhanced by the addition of Zn²⁺ ions to the grain media.

Hispidin是具有药理学性质的次生代谢产物，由药用蘑菇桑黄（Phellinus linteus）产生。在这项研究中，我们评价了金属离子加入到粒介质的影响而确定用于hispidin产量最佳照明和温度条件P.黄使用固态发酵03。在这些培养基中添加了六个金属离子，在最佳培养基温度和光照条件下，在这些培养基中生长的P. linteus 03用于组蛋白的生产。组氨酸的最高产量和比生产率以及组氨酸总含量在25°C的黑暗环境中实现，该条件在糙米和大麦米培养基的整个发酵过程中均保持不变。锌的添加在糙米培养基中添加²⁺离子可在发酵6周时获得最高的产量和比丝菌素产量以及总组织素含量；它们分别比对照中观察到的高2.53、2.62和2.43倍。这项研究表明，通过向谷物培养基中添加Zn ²⁺离子，可以增强LIN P. linteus 03产生的组蛋白。