New Dihydropyrrole-Substituted Epicatechins from Sun-Dried Dongting-Biluochun Tea Leaves and Their Inhibitory Activities on Acetylcholinesterase,ACS Food Science & Technology

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New Dihydropyrrole-Substituted Epicatechins from Sun-Dried Dongting-Biluochun Tea Leaves and Their Inhibitory Activities on Acetylcholinesterase
ACS Food Science & Technology ( IF 2.6 ) Pub Date : 2021-03-15 , DOI: 10.1021/acsfoodscitech.1c00057
Naixin Kang ₁ , Jianping Zhao ₂ , Ying Zhou ₁ , Zhiru Peng ₁ , Yanli Liu ₁ , Qiongming Xu ₁ , Ikhlas A. Khan _{1,

2} , Shilin Yang ₁

Affiliation

Although Dongting-Biluochun tea is one of the top 10 teas in China, little research has been done on its chemical composition. The phytochemical study of leaves of Dongting-Biluochun tea resulted in the isolation of two new dihydropyrrole-substituted epicatechins, (−)-6-(5″R)-2″-ethoxy-3″,4″-dihydro-2H-pyrrole-epicatechin-3-gallate (1) and (−)-6-(5″R)-2″-ethoxy-3″,4″-dihydro-2H-pyrrole-epicatechin (2), along with two known catechins, epicatechin-3-gallate (3) and epigallocatechin-3-gallate (4). The structures of compounds 1–4 were elucidated on the basis of spectroscopic and chemical analysis. In addition, bioactivity testing revealed that compounds 1, 3, and 4 possess strong acetylcholinesterase (AChE) inhibitory activity with IC₅₀ values of 42.38, 19.5, and 78.79 μM, respectively.

更新日期：2021-04-23

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