The phenomenological model for cell shape deformation and cell migration Chen (BMM 17:1429–1450, 2018), Vermolen and Gefen (BMM 12:301–323, 2012), is extended with the incorporation of cell traction forces and the evolution of cell equilibrium shapes as a result of cell differentiation. Plastic deformations of the extracellular matrix are modelled using morphoelasticity theory. The resulting partial differential differential equations are solved by the use of the finite element method. The paper treats various biological scenarios that entail cell migration and cell shape evolution. The experimental observations in Mak et al. (LC 13:340–348, 2013), where transmigration of cancer cells through narrow apertures is studied, are reproduced using a Monte Carlo framework.

细胞形状变形和细胞迁移的唯象模型 Chen (BMM 17:1429–1450, 2018), Vermolen and Gefen (BMM 12:301–323, 2012)，随着细胞牵引力和细胞进化的结合而得到扩展平衡形状是细胞分化的结果。使用形态弹性理论模拟细胞外基质的塑性变形。通过使用有限元方法求解得到的偏微分方程。该论文处理了需要细胞迁移和细胞形状进化的各种生物场景。Mak 等人的实验观察结果。(LC 13:340–348, 2013)，其中研究了癌细胞通过狭窄孔的迁移，使用蒙特卡洛框架进行复制。