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Transcription factor encoding of neuron subtype: Strategies that specify arbor pattern
Current Opinion in Neurobiology ( IF 4.8 ) Pub Date : 2021-04-23 , DOI: 10.1016/j.conb.2021.03.013
Yun Jin Pai 1 , Adrian W Moore 1
Affiliation  

Dendrite and axon arbors form scaffolds that connect a neuron to its partners; they are patterned to support the specific connectivity and computational requirements of each neuron subtype. Transcription factor networks control the specification of neuron subtypes, and the consequent diversification of their stereotyped arbor patterns during differentiation. We outline how the differentiation trajectories of stereotyped arbors are shaped by hierarchical deployment of precursor cell and postmitotic transcription factors. These transcription factors exert modular control over the dendrite and axon features of a single neuron, create spatial and functional compartmentalization of an arbor, instruct implementation of developmental patterning rules, and exert operational control over the cell biological processes that construct an arbor.



中文翻译:

神经元亚型的转录因子编码:指定乔木模式的策略

树突和轴突乔木形成支架,将神经元与其伙伴连接起来;它们被模式化以支持每个神经元亚型的特定连接和计算要求。转录因子网络控制神经元亚型的规范,以及随之而来的分化过程中其定型乔木模式的多样化。我们概述了刻板乔木的分化轨迹是如何通过前体细胞和有丝分裂后转录因子的分层部署来形成的。这些转录因子对单个神经元的树突和轴突特征进行模块化控制,创建乔木的空间和功能区室化,指导发育模式规则的实施,并对构建乔木的细胞生物过程施加操作控制。

更新日期:2021-04-23
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