The mitochondrial electron transport chain (ETC) has been an attractive target for cancer therapy due to its essentiality for tumor growth. Krall et al. found that under ETC dysfunction, a decrease in asparagine limits cancer cell proliferation and activates the integrated stress response, creating a therapeutically exploitable metabolic vulnerability.

中文翻译：

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天冬酰胺，细胞对线粒体功能障碍的反应的关键代谢物

由于其对肿瘤生长的重要性，线粒体电子传递链 (ETC) 已成为癌症治疗的一个有吸引力的目标。克拉尔等人。发现在 ETC 功能障碍下，天冬酰胺的减少会限制癌细胞增殖并激活综合应激反应，从而产生可用于治疗的代谢脆弱性。