The airways receive a dense supply of sensory nerve fibers that are responsive to damaging or potentially injurious stimuli. These airway nociceptors are mainly derived from the jugular and nodose vagal ganglia, and when activated they induce a range of reflexes and sensations that play an essential role in airway protection. Jugular nociceptors differ from nodose nociceptors in their embryonic origins, molecular profile and termination patterns in the airways and the brain, and recent discoveries suggest that excessive activity in jugular nociceptors may be central to the development of chronic cough. For these reasons, targeting jugular airway nociceptor signaling processes at different levels of the neuraxis may be a promising target for therapeutic development. In this focused review, we present the current understanding of jugular ganglia nociceptors, how they may contribute to chronic cough and mechanisms that could be targeted to bring about cough suppression.

气道接收密集供应的感觉神经纤维，这些纤维对破坏性或潜在伤害性的刺激有反应。这些气道伤害感受器主要来自颈静脉神经节和结节性迷走神经节，当被激活时，它们会诱发一系列反射和感觉，在气道保护中发挥重要作用。颈静脉伤害感受器在胚胎起源、分子特征和气道和大脑中的终止模式方面与结节伤害感受器不同，最近的发现表明，颈静脉伤害感受器的过度活动可能是慢性咳嗽发展的核心。由于这些原因，针对不同神经轴水平的颈静脉伤害感受器信号传导过程可能是治疗开发的一个有希望的目标。在这次重点审查中，