In the present effort, a highly responsive electrochemical sensor made up of a carbon nanotube paste electrode modified with a thin layer of electrochemically polymerised L-Leucine was employed for the determination of cetirizine (CTZ) in the presence of paracetamol. In contrast to bare carbon nanotube paste electrode (BCNTPE), a noticeable shift in the peak potential along with an enhancement in the peak current was observed for the electro‒oxidation of CTZ on the modified electrode surface, which can be associated to the extended microscopic active surface area of the modified electrode. The surface of both unmodified and modified electrode surfaces were characterized using field emission scanning electron microscopy (FE-SEM) and electron impedance spectroscopy (EIS) studies. The influence of experimental circumstances on the response of electrode, such as number of sweeping segments in the polymerisation process, accumulation potential, accumulation time, and the pH were examined. Under the optimized experimental conditions, the calibration plot was achieved in the concentration range from 5 μM to 50 μM of CTZ with a regression co-efficient of 0.996. The evaluated detection limit for CTZ was achieved as 0.17 μM. The proposed electrode and method were effectively utilized to analyse CTZ in pharmaceutical, blood serum and urine sample with a recovery of 96. 49‒99.85 %.

在目前的研究中，由扑热息痛存在下的西替利嗪（CTZ）测定采用由碳纳米管糊状电极修饰的高响应电化学传感器，其中碳纳米管糊状电极经电化学聚合的L-亮氨酸薄层修饰。与裸露的碳纳米管糊状电极（BCNTPE）相比，在改性电极表面上CTZ的电氧化可观察到峰电位的明显变化以及峰电流的增加，这可能与扩展的微观结构有关修饰电极的有效表面积。使用场发射扫描电子显微镜（FE-SEM）和电子阻抗谱（EIS）研究来表征未修饰和修饰电极表面。检查了实验环境对电极响应的影响，例如聚合过程中扫掠链段的数量，累积电势，累积时间和pH值。在优化的实验条件下，在5μM至50μM的CTZ浓度范围内获得了校正图，回归系数为0.996。CTZ的评估检测下限达到0.17μM。所提出的电极和方法可有效地用于分析药物，血清和尿液样品中的CTZ，回收率为96. 49％99.85％。在5 µM至50 µM CTZ的浓度范围内获得了校正图，回归系数为0.996。CTZ的评估检测下限达到0.17μM。所提出的电极和方法可有效地用于分析药物，血清和尿液样品中的CTZ，回收率为96. 49％99.85％。在5 µM至50 µM CTZ的浓度范围内获得了校正图，回归系数为0.996。CTZ的评估检测下限达到0.17μM。所提出的电极和方法可有效地用于分析药物，血清和尿液样品中的CTZ，回收率为96. 49％99.85％。