Objective

Evidence supports the relationship between the skin barrier and allergic conditions. This narrative review evaluates what role the cutaneous barrier may play in the pathogenesis, disease course, and management of allergic rhinitis (AR).

Data Sources

A literature review of the MEDLINE (PubMed), Embase, Cochrane, and SCOPUS Sciverse databases was conducted to identify available evidence. Reference lists of pertinent papers were searched using a snowball technique.

Study Selections

Papers published in English from all years until December 2020 were included. Papers that did not address the relationship between AR and the skin and hypothesis papers were excluded.

Results

The cutaneous barrier shares histologic characteristics with the sinonasal epithelial barrier, which may explain commonalities between AR and atopic dermatitis. A disruption in the epithelial barrier could be a common pathway in the development of multiple allergic conditions. The skin is a common target for the treatment of AR. Available data that look at the relationship between the skin and AR often include other topics such as other atopic disorders and the role of the epithelial barrier. Increased understanding of how the cutaneous barrier affects AR may lead to new innovations in its management.

Conclusion

The connection between the cutaneous barrier and AR holds possibilities for further investigation, and these may lead to a better understanding and future innovations for all atopic diseases.

中文翻译：

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我鼻子上没有皮

客观的

有证据支持皮肤屏障与过敏性疾病之间的关系。这篇叙述性综述评估了皮肤屏障在过敏性鼻炎 (AR) 的发病机制、病程和管理中可能发挥的作用。

数据源

对 MEDLINE (PubMed)、Embase、Cochrane 和 SCOPUS Sciverse 数据库进行了文献回顾，以确定可用的证据。使用滚雪球技术搜索相关论文的参考列表。

研究选择

包括从所有年份到 2020 年 12 月以英文发表的论文。没有解决 AR 与皮肤之间关系的论文和假设论文被排除在外。

结果

皮肤屏障与鼻窦上皮屏障具有相同的组织学特征，这可以解释 AR 和特应性皮炎之间的共同点。上皮屏障的破坏可能是多种过敏性疾病发展的常见途径。皮肤是治疗 AR 的常见目标。查看皮肤和 AR 之间关系的可用数据通常包括其他主题，例如其他特应性疾病和上皮屏障的作用。对皮肤屏障如何影响 AR 的更多了解可能会导致其管理的新创新。

结论

皮肤屏障和 AR 之间的联系为进一步研究提供了可能性，这可能会导致对所有特应性疾病的更好理解和未来创新。