This essay discusses the new report, Heritable Human Genome Editing, by the National Academy of Medicine, the National Academy of Sciences, and the Royal Society. After summarizing the report, we argue that the report takes four quite bold steps away from prior reports, namely (1) rejecting an omnibus approach to heritable human genome editing (HHGE) in favor of a case-by-case analysis of possible uses of HHGE, accepting that HHGE is acceptable in some cases; (2) recognizing that the interest in having children who are genetically related to both would-be rearing parents is one that the regulation of HHGE should honor; (3) patterning a regulatory model for HHGE on the United Kingdom's approach to regulating mitochondrial replacement techniques; and (4) conveying skepticism that international regulation is possible while showing a strong preference for a default into national regulatory regimes for HHGE.

中文翻译：

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可遗传人类基因组编辑报告中的法律和伦理问题

这篇文章讨论了新报告，可遗传的人类基因组编辑，由美国国家医学科学院、美国国家科学院和皇家学会提供。在总结报告后，我们认为该报告与之前的报告相比采取了四个相当大胆的步骤，即 (1) 拒绝对可遗传人类基因组编辑 (HHGE) 的综合方法，支持对可能的用途进行逐案分析HHGE，接受 HHGE 在某些情况下是可以接受的；(2) 认识到生育与父母双方都有遗传关系的孩子的兴趣是 HHGE 的规定应该尊重的；(3) 在英国调控线粒体置换技术的方法上构建 HHGE 调控模型；(4) 表达对国际监管的可能性的怀疑，同时表现出强烈倾向于违约进入 HHGE 的国家监管制度.