Background and Aims. A relevant role is emerging for functional foods in cardiovascular prevention. The aim of this study was to assess the effect of a nutraceutical multitargeted approach on lipid profile and inflammatory markers along with vascular remodelling in a cohort of dyslipidemic subjects without history of cardiovascular (CV) disease. Methods and Results. We enrolled 25 subjects (mean age 48.2 years) with low to moderate CV risk profile and total cholesterol (TC) levels between 150 and 250 mg/dl. The patients were assigned to receive for one year a tablet/die of a nutraceutical combination containing red yeast rice (RYR) extract (Monacolin 3 mg/tablet) and coenzyme Q10 (30 mg/tablet). Treatment with the nutraceutical compounds led to a significant reduction of TC (from 227 to 201 mg/dl, ), LDL-c (from 150 to 130 mg/dl, ), triglycerides (from 121 to 109 mg/dl, ), non-HDL-cholesterol (from 168 to 141 mg/dl, ), hs-CRP (from 1.74 to 1.20 mg/l, ), and osteoprotegerin (from 1488 to 1328 pg/ml, ). Levels of HDL-c, Lp(a), glucose, liver enzyme, CPK, or creatinine did not change over time. An ultrasound study was performed to assess changes in mean carotid intima-media thickness (IMT) and maximum IMT (M-MAX) as well as modification in local carotid stiffness by means of determining the carotid compliance coefficient (CC) and distensibility coefficient (DC). At the end of the treatment, we observed small but significant reductions in both mean-IMT (from 0.62 to 0.57 mm, ) and M-MAX (from 0.79 to 0.73 mm, ), and an improvement in carotid elasticity (DC from 22.4 to , and CC from 0.77 to 0.85 mm²/kPa, ). Conclusions. A long-term treatment with a combination of RYR and coenzyme Q10 showed lipid-lowering activity along with a reduction of inflammatory mediators and an improvement of vascular properties in young subjects with a low-to-moderate CV risk profile.

中文翻译：

---

使用红曲米提取物治疗的年轻血脂异常受试者的血脂谱和血管重塑

背景和目标。功能性食品在心血管预防中的相关作用正在显现。本研究的目的是评估营养保健多靶点方法对一组无心血管 (CV) 病史的血脂异常受试者的血脂谱、炎症标志物以及血管重塑的影响。方法和结果。我们招募了 25 名受试者（平均年龄 48.2 岁），他们的心血管风险状况为低至中度，且总胆固醇 (TC) 水平在 150 至 250 mg/dl 之间。患者被分配接受为期一年的含有红曲米 (RYR) 提取物（Monacolin 3 毫克/片）和辅酶 Q10（30 毫克/片）的营养保健组合的片剂/模具。营养保健化合物治疗导致 TC 显着降低（从 227 毫克/分升降至 201 毫克/分升，）、 LDL-c（从 150 至 130 mg/dl，）、甘油三酯（121 至 109 mg/dl，）、非 HDL 胆固醇（从 168 至 141 mg/dl，）、 hs-CRP（从 1.74 至 1.20 毫克/升，）和骨保护素（从 1488 到 1328 pg/ml，）。HDL-c、Lp(a)、葡萄糖、肝酶、CPK 或肌酐水平不随时间变化。进行超声研究以评估平均颈动脉内膜中层厚度 (IMT) 和最大 IMT (M-MAX) 的变化，以及通过确定颈动脉顺应系数 (CC) 和扩张系数 (DC) 来评估局部颈动脉僵硬度的变化）。治疗结束时，我们观察到平均 IMT 均出现小幅但显着的下降（从 0.62 毫米降至 0.57 毫米，）和 M-MAX（从 0.79 到 0.73 毫米，），以及颈动脉弹性的改善（DC从22.4到, 和 CC 从 0.77 至 0.85 mm ² /kPa，）。 结论。RYR 和辅酶 Q10 组合的长期治疗显示出降脂活性，同时减少了炎症介质，并改善了具有低至中度心血管风险的年轻受试者的血管特性。