The potential of albumin-coated hollow mesoporous silica nanoparticles (A-HMSNs) to optimize the chemotherapeutic efficacy of docetaxel (DTX) was explored. The synthesized A-DTX-HMSNs had a nanometric size range, offered large surface area with numerous pores, and offered high drug entrapment and loading, that is, 79.18% ± 1.4% and 19.11% ± 1.30%, respectively. Fourier transform infrared spectroscopy and differential scanning calorimetry studies confirmed drug loading and the presence of albumin onto the developed systems, and the drug release followed Higuchi profile. A-HMSNs significantly enhanced the pharmacokinetic profile of DTX by eightfold vis-à-vis the pure DTX. The enhanced plasma levels (C_max, T_max, area under the curve), prolonged drug release, long circulation time, lower clearance, hemocompatability, and substantially higher drug loading offered by these nanocarriers inherit promise of a safer and efficacious formulation of DTX.

中文翻译：

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多西紫杉醇的白蛋白包覆介孔二氧化硅纳米颗粒：制备、表征和药代动力学评价

探索了白蛋白包被的中空介孔二氧化硅纳米粒子 (A-HMSN) 优化多西紫杉醇 (DTX) 化疗功效的潜力。合成的 A-DTX-HMSNs 具有纳米尺寸范围，提供大表面积和众多孔，并提供高药物包封和负载，即分别为 79.18% ± 1.4% 和 19.11% ± 1.30%。傅里叶变换红外光谱和差示扫描量热法研究证实了所开发系统上的药物负载和白蛋白的存在，并且药物释放遵循 Higuchi 曲线。与纯 DTX 相比，A-HMSN 显着增强了 DTX 的药代动力学特征八倍。提高的血浆水平 ( C _max , T _max, 曲线下面积)、延长药物释放、长循环时间、较低的清除率、血液相容性和这些纳米载体提供的显着更高的载药量继承了更安全和有效的 DTX 制剂的前景。