The prevalence of food allergy (FA) is increasing, and there is an urgent need to take effective measures against it. One important measure is the avoidance diet, which shows a disadvantage, especially in case of accidental exposure. Oral tolerance restoration sheds new light on the control of FA. Oral tolerance is naturally a state of systemic unresponsiveness of the gastrointestinal tract to food antigens and its restoration can be a clinical therapy for FA. Its immune basis lies on the intestinal mucosal immune system and factors, such as gut microbiota and food processing methods, are also important. This review presents recent advances in oral tolerance and its closely related factors.
Int Arch Allergy Immunol

中文翻译：

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通过诱导口腔耐受来对抗食物过敏：事实与虚构

食物过敏（FA）的流行率正在增加，迫切需要采取有效措施加以应对。一个重要的措施是避免饮食，这显示了一个缺点，特别是在意外接触的情况下。口腔耐受性恢复为 FA 的控制提供了新的思路。口服耐受自然是胃肠道对食物抗原的全身性无反应状态，其恢复可以作为 FA 的临床治疗。其免疫基础在于肠黏膜免疫系统，肠道微生物群和食品加工方法等因素也很重要。本综述介绍了口服耐受性及其密切相关因素的最新进展。
Int Arch 过敏免疫