Whole lung irradiation (WLI) has been used successfully in humans as an adjuvant treatment for osteosarcoma. The aim of this study is to describe the feasibility and safety of WLI in dogs with appendicular osteosarcoma. Twelve client-owned dogs with appendicular osteosarcoma that had successfully completed amputation and four doses of carboplatin without evidence of gross metastasis were enrolled in this prospective clinical trial. Ten once-daily fractions of 1.75 Gy were administered to the planning target volume encompassing the lungs. Overall, WLI was well tolerated in these patients. No dogs developed symptoms of pneumonitis or pulmonary fibrosis. Haematopoietic toxicity evaluated during radiation therapy was found to be mild. The median disease free interval for WLI treated dogs was not significantly different than the median DFI for a group of historic control dogs (376 days for WLI treated dogs versus 304.5 days for control dogs; p = 0.5461). Although no significant improvement in outcome was observed with this study, WLI appears to be safe in dogs and warrants further investigation to characterize the efficacy and toxicity.

中文翻译：

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全肺照射治疗犬附肢骨肉瘤的可行性和安全性

全肺照射 (WLI) 已成功用于人类作为骨肉瘤的辅助治疗。本研究的目的是描述 WLI 在患有阑尾骨肉瘤的狗中的可行性和安全性。这项前瞻性临床试验招募了 12 只患有阑尾骨肉瘤的客户自备狗，这些狗已成功完成截肢和 4 剂卡铂，但没有出现明显转移的证据。每天 10 次 1.75 Gy 的部分被给予包括肺部的计划目标体积。总体而言，这些患者对 WLI 的耐受性良好。没有狗出现肺炎或肺纤维化的症状。发现在放射治疗期间评估的造血毒性是轻微的。p  = 0.5461）。尽管这项研究没有观察到结果的显着改善，但 WLI 似乎对狗是安全的，需要进一步研究以表征疗效和毒性。