The design of industrial crystallization processes usually employs laboratory-scale experimental data which must be correlated with the full-scale process for effective technology transfer. In this context, the measured growth rates of single crystals of ibuprofen in stagnant ethanolic solutions are compared with data recorded for a population of crystals crystallized in an agitated 7-mL reactor. The single crystal growth rates are found to be rather close to those determined in the agitated reactor, with both being also in good agreement with previously published data at the 750-mL scale, suggesting that studies on single crystals can have utility for the purpose of crystallization process design and optimization.

中文翻译：

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布洛芬的测量增长率：比较单晶和散装悬浮液数据

工业结晶过程的设计通常采用实验室规模的实验数据，这些数据必须与有效技术转移的全规模过程相关联。在这种情况下，将测得的布洛芬单晶在静止乙醇溶液中的生长速率与在搅拌的 7 毫升反应器中结晶的晶体群记录的数据进行比较。发现单晶生长速率与在搅拌反应器中确定的相当接近，两者也与先前公布的 750 mL 规模的数据非常吻合，这表明对单晶的研究可用于结晶工艺设计与优化。