The crystal structure of pazopanib hydrochloride Form 1 has been refined using synchrotron X-ray powder diffraction data and optimized using density functional theory techniques. Pazopanib hydrochloride crystallizes in space group P-1 (#2) with a = 8.45008(6), b = 8.71310(12), c = 16.05489(35) Å, α = 79.5996(9), β = 86.4784(5), γ = 87.3764(3)°, V = 1159.724(9) Å3, and Z = 2. The crystal structure is essentially identical to that of CSD Refcode CEVYEK. There are four strong N–H⋯Cl hydrogen bonds to the chloride anion. Several additional weaker N–H⋯Cl and C–H⋯Cl hydrogen bonds are also present. A variety of C–H⋯O, C–H⋯N, and N–H⋯S hydrogen bonds also contribute to the lattice energy. The powder pattern has been submitted to ICDD® for inclusion in the Powder Diffraction File™.

中文翻译：

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盐酸帕唑帕尼 1 型 C21H24N7O2SCl 的粉末 X 射线衍射

盐酸帕唑帕尼 1 型的晶体结构已使用同步加速器 X 射线粉末衍射数据进行了细化，并使用密度泛函理论技术进行了优化。盐酸帕唑帕尼在空间群中结晶磷-1 (#2) 与一种= 8.45008(6),b= 8.71310(12),C= 16.05489(35) 埃，α= 79.5996(9),β= 86.4784(5),γ= 87.3764(3)°,五= 1159.724(9) Å3， 和Z= 2. 晶体结构与 CSD Refcode CEVYEK 基本相同。与氯阴离子有四个强 N-H⋯Cl 氢键。还存在几个额外的较弱的 N-H⋯Cl 和 C-H⋯Cl 氢键。各种 C-H⋯O、C-H⋯N 和 N-H⋯S 氢键也对晶格能有贡献。粉末图案已提交给ICDD®包含在粉末衍射文件™中。